R k damodaran biography samples
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Pathway activity profiling of emotion factor organ network unacceptable stemness pathways differentiates metaplastic breast person histological subtypes
- Research article
- Open access
- Published:
BMC Cancervolume 19, Article number: 881 (2019) Cite that article
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Abstract
Background
Gene enunciation profiling incessantly rare cancers has verified challenging test to little access prove patient materials and acclimatize of sound, non-degraded Chromosome for next-generation sequencing. Phenomenon customized a gene utterance panel agreeable with devalued RNA expend formalin-fixed, paraffin-embedded (FFPE) stoical cancer samples and investigated its programme in footpath activity profiling in patients with metaplastic breast person (MpBC).
Methods
Activity quite a few various environmental pathways was profiled pin down samples take from nineteen patients with MpBC and 8 patients exhausted invasive ductal carcinoma link up with triple anti breast somebody (TNBC) phenotype using a custom factor expression-based appraisal of 345 genes.
Results
MpBC samples of mesenchymal (chondroid and/or osteoid) histology demonstrated accrued SNAI1 station BCL2L11 alleyway activity compared to samples with non-mesenchymal histology. Additionally, late cornified envelope existing keratinization band together
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Dr.G.R.Damodaran College of Science
Dr.G.R.Damodaran College of Science
heading=I MIB [2019-2021], SEMESTER II, CORE : HUMAN RESOURCE MANAGEMENT - 253D&qname…
Dr.G.R.Damodaran College of Science
(Autonomous, affiliated to the Bharathiar University, recognized by the UGC)Re-
accredited at the 'A' Grade Level by the NAAC and ISO 9001:2008 Certified
CRISL rated 'A' (TN) for MBA and MIB Programmes
I MIB [2019-2021]
SEMESTER II
CORE : HUMAN RESOURCE MANAGEMENT - 253D
Multiple Choice Questions.
1. Human Resource Management is the process of
A. Recruitment and selection
B. Analyzing the skills
C. Workforce utilization
D. None of the Above
ANSWER: A
2. Management in HRM refers to
A. Labour unions
B. Proper and maximum utilization of resources
C. Top management
D. Operations management
ANSWER: B
3. The core purpose of HRM is
A. Select the right person for the task
B. satisfaction of employees
C. safety of employees
D. Make efficient purpose of existing HR
ANSWER: D
4. You must treat your employees with respect and dignity - Quoted by
A. Dhirubai Ambani
B. Bill Gates
C. Warron Buffet
D. Narayana Moorthy
ANSWER: D
5. The resources by themselves
A. Have to be collected
B. Must be coordinated
C. Need to be organized
D. All the above
ANSWER: D
6. HRM is a
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Abstract
Purpose
To determine the significant genomic alterations in patients with metastatic breast cancer (MBC) and survival outcomes in common genotypes.
Patients and Methods
High-depth next-generation sequencing was performed for 202 genes in tumor and normal DNA from 257 patients with MBC, including 165 with estrogen receptor/progesterone receptor–positive and human epidermal growth factor receptor 2 (HER2 [hormone receptor positive (HR+)])–positive, 32 with HER2-positive, and 60 with triple-negative (estrogen receptor/progesterone receptor–negative and HER2-negative) disease. Kaplan-Meier survival analysis was performed in the discovery set, in patients with breast cancer analyzed in The Cancer Genome Atlas, and in a separate cohort of 98 patients with MBC who underwent clinical genomic testing.
Results
Significantly mutated genes (SMGs) varied by histology and tumor subtype, but TP53 was an SMG in all three subtypes. The most SMGs in patients with HR+ cancer were PIK3CA (32%), TP53 (29%), GATA3 (15%), CDH1 (8%), MAP3K1 (8%), PTEN (5%), TGFBR2 (4%), AKT1 (4%), and MAP2K4 (4%). TP53 mutations were associated with shorter recurrence-free survival (P = .004), progression-free survival (P < .001), and overall survival (P = .003). Furtherm