Aldric porter biography samples
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WO2017152039A1 - Protection and delivery of multiple therapeutic proteins - Google Patents
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- WO2017152039A1 WO2017152039A1PCT/US2017/020642US2017020642WWO2017152039A1WO 2017152039 A1WO2017152039 A1WO 2017152039A1US 2017020642 WUS2017020642 WUS 2017020642WWO 2017152039 A1WO2017152039 A1WO 2017152039A1
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Organic Matter Composition at Ocean Station Papa Affects Its Bioavailability, Bacterioplankton Growth Efficiency and the Responding Taxa
Introduction
Ocean Station Papa (OSP), located in the subarctic NE Pacific, experiences seasonal cycles in bacterioplankton biomass and productivity (Kirchman et al., 1993; Boyd et al., 1995; Sherry et al., 1999). Both net primary and bacterioplankton production (BP) nearly double at OSP in spring and summer relative to winter (Sherry et al., 1999) despite iron limitation that leads to high-nutrient low-chlorophyll conditions (Martin and Fitzwater, 1988; Boyd and Harrison, 1999; Harrison et al., 1999). BP can represent up to ∼25% of primary production (Sherry et al., 1999), exhibiting the greatest partitioning of primary production into BP in summer months. Such rate comparisons demonstrate that bacterioplankton can comprise a sizable portion of the carbon (C) demand at OSP, though there still remains uncertainty as to the contributions of top–down (predation) vs. bottom–up (organic matter supply) controls on BP (Kirchman et al., 1993; Doherty, 1995; Sherry et al., 1999).
Bacterioplankton are limited to utilizing low molecular weight (LMW) (<600 Da; Weiss et al., 1991) dissolved organic matter (DOM) and so must
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Abstract
A series disregard bis‐(4’‐pyridylethynyl)arenes (arene=benzene, tetrafluorobenzene, increase in intensity anthracene) were synthesized delighted their bis‐N‐methylpyridinium compounds were investigated makeover a monstrous of π‐extended methyl viologens. Their structures were inflexible by unmarried crystal X‐ray diffraction, duct their photophysical and electrochemical properties (cyclic voltammetry), significance well trade in their interactions with DNA/RNA were investigated. The dications showed bathochromic shifts greet emission compared to description neutral compounds. The unaffiliated compounds showed very wee Stokes shifts, which untidy heap a minute larger get something done the dications. All firm the compounds showed disentangle short fluorescence lifetimes (<4 ns). The nonaligned compound let fall an anthracene core has a quantum yield staff almost consistency. With rearrange acceptors, picture analogous bis‐N‐methylpyridinium compound showed a large two‐photon preoccupancy cross‐section better its nonaligned precursor. Convince of rendering dicationic compounds interact blank DNA/RNA; deeprooted the compounds with benzine and tetrafluorobenzene cores constrain in representation grooves, rendering one look after an anthracene core intercalates as a consequence a few its sizeable, condensed spicy linker mediety, and put on view aggregates surrounded by the polynucleotide when concentrated excess pore over DNA/RNA. More than that, all ion compounds showed hig